Light - Red and Near-infrared
Numerous therapeutic uses in the low level light application of this frequency band
Red and near-infrared light (NIR) profoundly influences biological systems through photobiomodulation mechanisms, impacting cellular energy metabolism, redox states, and systemic regulation. This section examines the effects of red and NIR light, exploring its interactions with cellular targets, modulation of bioelectric and biochemical pathways, and therapeutic applications. ...
Recent evidence highlights its roles in tissue repair, inflammation reduction, and potential anti-cancer effects, emphasizing its relevance for integrative medicine and biophysics.
Red (600–700 nm) and near-infrared light (700–1000 nm) are non-ionizing radiations that penetrate biological tissues, exerting effects at cellular and systemic levels. Photobiomodulation (PBM) using these wavelengths has demonstrated significant therapeutic benefits in diverse contexts, including wound healing, inflammation modulation, and neuronal recovery. This section synthesizes current knowledge on the mechanisms, biological effects, and clinical potential of red and NIR light.Mechanisms of Action:
Cellular Targets and Energy Modulation:
Early models attributed PBM effects to cytochrome c oxidase (CCO) activation in mitochondria. However, recent studies question this exclusivity, highlighting roles for interfacial water layers and calcium fluxes (Sommer et al., 2019).
NIR light enhances the activity of mitochondrial enzymes such as complex IV, while other complexes show varied responses, indicating nuanced effects on electron transport (Pope & Denton, 2023).
Bioelectric and Biochemical Pathways:
Red and NIR light interact with cellular membranes, inducing depolarization and modulating ion channel activities, particularly calcium flux via NMDA receptors (Golovynska et al., 2019).
Reactive oxygen species (ROS) generation under controlled conditions supports redox signaling and tissue regeneration.
Biological Effects:
Tissue Repair and Anti-Inflammatory Responses:
PBM accelerates wound healing by stimulating fibroblast proliferation, collagen synthesis, and angiogenesis (Hamblin et al., 2018).
NIR light reduces inflammatory cytokine levels, supporting recovery in chronic inflammatory conditions.
Neuroprotection and Cognitive Enhancement:
Transcranial NIR exposure improves neuronal recovery and synaptic plasticity, offering therapeutic potential for neurodegenerative diseases and brain injuries (Yusupov et al., 2018).
Studies reveal enhanced glutamate release and biophoton transmission in neural circuits, linking PBM to cognitive processes.
Anti-Cancer Potential:
Low-level NIR light selectively modulates redox states in cancer and healthy cells, influencing tumor microenvironments and cellular proliferation (de Faria et al., 2020).
PBM’s ability to restore tissue homeostasis underpins its potential as an adjunct in cancer therapy.
Interaction with Structured Water and Bioelectric Fields:
Structured Water Layers:
Red and NIR light modulate interfacial water properties, enhancing exclusion zone (EZ) water formation and bioelectric conductivity (Santana-Blank et al., 2016).
These interactions underpin energy storage and transfer mechanisms, bridging molecular and systemic scales.
Bioelectric Networks:
PBM aligns cellular activities through bioelectric field modulation, supporting tissue coherence and regenerative processes (Korotkov, 2020).
Therapeutic Applications:
Clinical Uses:
Red and NIR light therapy has shown efficacy in treating musculoskeletal disorders, chronic wounds, and neurodegenerative diseases.
Emerging applications include brain stimulation, anti-aging therapies, and adjunctive cancer treatments.
Innovative Technologies:
Advances in wearable NIR devices and targeted PBM delivery systems enhance accessibility and precision in therapeutic contexts.
Discussion: The diverse effects of red and NIR light highlight its role in modulating biological systems through photonic and bioelectric pathways. While established mechanisms like mitochondrial activation provide foundational understanding, emerging research on structured water and biophoton-mediated communication expands the scope of PBM. Integrating these insights into clinical practice offers new avenues for treating complex conditions and optimizing health.
Conclusion: Red and near-infrared light serve as versatile tools in biomedicine, influencing cellular energy dynamics, systemic coherence, and therapeutic outcomes. By harnessing its biological effects, PBM holds promise for advancing integrative healthcare and understanding life’s photonic underpinnings.
Keywords: red light, near-infrared light, photobiomodulation, tissue repair, neuroprotection, anti-inflammatory, bioelectric fields, structured water, exclusion zones.
-Text generated by AI superficially, for more specific but also more surprising data check the tables below-Very related sections:
↑ text updated (AI generated): 28/12/2024
↓ tables updated (Human): 03/11/2024
Applied Fields - Experimental
Light - Red and near-infrared - (630-1000 nm)
Various Experimental findings and Proposals of red and near-infrared light Targets ║ Transcraneal red and near-infrared light exposure and/or Neuronal functional recovery ║ Red and infra-red light for Inflamation Reduction ║ Posibble Anti-Cancer properties of low-level red and infrared light ║ Other Therapeutic Uses of low-level red and infrared light
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|
| F |  | Differential effects of 808-nm light on electron transport chain enzymes in isolated mitochondria: Implications for photobiomodulation initiation | 808 nm - (0.6-4 mW/cm2) |  | 2023-(10) | Nathaniel J. Pope, Michael L. Denton |
| F |  | Effects of 660 Nm Laser Irradiation of Soybean Seeds on Germination, Emergence and Seedling Growth | 660 nm - 0.8-3.2 J/cm2 (3.5 mW/cm2) | | 2021-(14) | Yuri Sarreta, Jarbas C. de Castro Neto |
| A |  | Influence of far-red light coherence on functional state of plants | 730 nm |  | 2021-(1) | A. V. Budagovsky, N. V. Solovykh, O. N. Budagovskaya, I. A. Budagovsky |
| F | | Effects of photobiomodulation on the redox state of healthy and cancer cell [preprint] | 780 nm - 5 J/cm2 | | 2020-(8) | Clara Maria Gonçalves de Faria, Heloisa Ciol, Vanderlei Salvador Bagnato, Sebastião Pratavieira |
| F | | Quantum biology in low level light therapy: death of a dogma (water) | - | | 2020-(11) | Andrei P. Sommer, Peter Schemmer, Attila E. Pavláth, Horst-Dieter Försterling, Ádám R. Mester, Mario A. Trelles |
| A | | Biphasic Dose/Response of Photobiomodulation Therapy on Culture of Human Fibroblasts | 669 nm | | 2020-(1) | Genoveva Lourdes Flores Luna, Ana Laura Martins de Andrade, Patricia Brassolatti, Paulo Sérgio Bossini, Fernanda de Freitas Anibal, Nivaldo Antonio Parizotto, Ângela Merice de Oliveira Leal |
| A | | The 808 nm and 980 nm infrared laser irradiation affects spore germination and stored calcium homeostasis: A comparative study using delivery hand-pieces with standard (Gaussian) or flat-top profile (water) | 808-980 nm - (100-2000 mW/cm2) | | 2019-(1) | Sara Ferrando, Dimitrios Agas, Serena Mirata, Antonio Signore, Nicola De Angelis, Silvia Ravera, Anatoliy S. Utyuzh, Steven Parker, Maria Giovanna Sabbieti, Stefano Benedicenti, Andrea Amaroli |
| F | | Revisiting the Photon/Cell Interaction Mechanism in Low-Level Light Therapy (no mitocon.) | - | | 2019-(6) | Andrei P. Sommer |
| A | | Photobiomodulation enhancement of cell proliferation at 660 nm does not require cytochrome c oxidase (no mitocon.) | 660 nm | | 2019-(1) | Paula L. V. Lima, Claudia V. Pereira, Nadee Nissanka, Tania Arguello, Giulio Gavini, Carlos Magno da Costa Maranduba, Francisca Diaz, Carlos T. Moraes |
| A | | Red and near‐infrared light induces intracellular Ca2+ flux via the activation of glutamate N‐methyl‐D‐aspartate receptors | 650 nm, 808 nm - (1-300 mW/cm2) | | 2019-(1) | Iuliia Golovynska, Sergii Golovynskyi, Yurii V. Stepanov, Liudmyla V. Garmanchuk, Ludmila I. Stepanova, Junle Qu Tymish, Y. Ohulchanskyy |
| F | | Effect of Infrared Light on Protein Behavior in Contact with Solid Surface (protein interfacial water) [preprint] | - | | 2018-(44) | Magdalena Kowacz, Piotr Warszyński |
| F | | Beyond esterase-like activity of serum albumin. Histidine-(nitro)phenol radical formation in conversion cascade of p-nitrophenyl acetate and the role of infrared light (water) [preprint] | 2900 nm | | 2018-(21) | Magdalena Kowacz, Piotr Warszyński |
| F | | The Regulatory Effect of Low-Intensity Radiation in the Near-Infrared Region on the Early Development of Zebrafish (Danio rerio) | 630-930 nm - 0.0000024 J/cm2, 0.0024-2.4 J/cm2 | | 2018-(7) | V. I. Yusupov, N. B. Simonova, G. M. Chuiko, E. I. Golovkina, V. N. Bagratashvili |
| F |  | Effect of red light and near infrared laser on the generation of reactive oxygen species in primary dermal fibroblasts | 638 nm, 825 nm - 5-25 J/cm2 | | 2018-(22) | Sajan George, Michael R. Hamblin, Heidi Abrahamse |
| A | | Photobiomodulation effects on mRNA levels from genomic and chromosome stabilization genes in injured muscle | 904 nm - 3J/cm2 | | 2018-(1) | Larissa Alexsandra da Silva Neto Trajano, Eduardo Tavares Lima Trajano, Luiz Philippe da Silva Sergio, Adilson Fonseca Teixeira, Andre Luiz Mencalha, Ana Carolina Stumbo, Adenilson de Souza da Fonseca |
| A | | Near-infrared laser photons induce glutamate release from cerebrocortical nerve terminals | - | | 2018-(1) | Andrea Amaroli, Manuela Marcoli, Arianna Venturini, Mario Passalacqua, Luigi F. Agnati, Antonio Signore, Mirco Raffetto, Guido Maura, Stefano Benedicenti, Chiara Cervetto |
| F | | Non-mammalian Hosts and Photobiomodulation: Do All Life-forms Respond to Light? | (review) | | 2018-(14) | Michael R Hamblin, Ying-Ying Huang, Vladimir Heiskanen |
| F | | Effects of pulsing of light on the dentinogenesis of dental pulp stem cells in vitro | 810 nm - (0.00128 mW/cm2) | | 2018-(11) | Hong Bae Kim, Ku Youn Baik, Hoon Seonwoo, Kyoung-Je Jang, Myung Chul Lee, Pill-Hoon Choung , Jong Hoon Chung |
| F | | Effect of Red-to-Near Infrared Light on the Reaction of Isolated Cytochrome c Oxidase with Cytochrome c (no mitocon.) | 660 nm - (4.6 mW/cm2) | | 2016-(7) | Brendan J. Quirk, Harry T. Whelan |
| F | | ‘‘Quantum Leap’’ in Photobiomodulation Therapy Ushers in a New Generation of Light-Based Treatments for Cancer and Other Complex Diseases: Perspective and Mini-Review(water) | (review) | | 2016-(9) | Luis Santana-Blank, Elizabeth Rodríguez-Santana, Karin E. Santana-Rodríguez, Heberto Reyes |
| A | | Infrared light-induced protein crystallization. Structuring of protein interfacial water and periodic self-assembly (water) | 2900-3200 nm | | 2016-(7) | Magdalena Kowacz, Mateusz Marchel, Lina Juknaité, José M.S.S. Esperança, Maria João Romão, Ana Luísa Carvalh, Luís Paulo N. Rebelo |
| F | | Water's Many Roles in Laser Photobiomodulation (water) | (review) | | 2015-(5) | Luis Santana-Blank, Elizabeth Rodríguez-Santana, Karin E. Santana-Rodríguez, Jesús A. Santana-Rodríguez, Heberto Reyes |
| F | | Action-Dependent Photobiomodulation on Health, Suboptimal Health, and Disease (enviro.) | (review) | | 2014-(11) | Timon Cheng-Yi Liu, Long Liu, Jing-Gang Chen, Peng Zeng, Xiang-Bo Yang |
| F | | Microenvironment Dependent Photobiomodulation on Function-Specific Signal Transduction Pathways (enviro.) | (review) | | 2014-(8) | Timon Cheng-Yi Liu, De-Feng Wu, Ling Zhu, P. Peng, Long Liu, Xiang-Bo Yang |
| F | | Lightening up Light Therapy: Activation of Retrograde Signaling Pathway by Photobiomodulation (mitocon. water) | (review) | | 2014-(6) | Hong Pyo Kim |
| F | | Photobiostimulation in C. elegans as a Model for Low Level Light Therapy | 920-980 nm - 5 J/cm2 | | 2014-(16) | Michael J. Spoto, Daryl D. Hurd |
| A | | Absorption of monochromatic and narrow band radiation in the visible and near IR by both mitochondrial and non-mitochondrial photoacceptors results in photobiomodulation (various) | (review) | | 2014-(1) | Salvatore Passarella, Tiina Karu |
| A | | Emerging evidence on the crystalline water-light interface in ophthalmology and therapeutic implications in photobiomodulation: first communication (water) | (review) | | 2014-(1) | Luis Santana-Blank, Elizabeth Rodríguez-Santana |
| F | | Water-light interaction: A novel pathway for multi hallmark therapy in cancer (water) | (review) | | 2013-(6) | Luis Santana-Blank, Elizabeth Rodríguez-Santana, Heberto Reyes, Jesús A. Santana- Rodríguez, Karin E. Santana-Rodríguez |
| F | | Laser photobiomodulation: A new promising player for the multi-hallmark treatment of advanced cancer (water) | (review) | | 2013-(3) | Luis Santana-Blank, Elizabeth Rodríguez-Santana, Heberto Reyes, Jesús A. Santana- Rodríguez, Karin E. Santana-Rodríguez |
| A | | Photobiomodulation of Aqueous Interfaces: Finding Evidence to Support the Exclusion Zone in Experimental and Clinical Studies (water) | (review) | | 2013-(1) | Luis Santana-Blank, Elizabeth Rodríguez-Santana, Karin E. Santana-Rodríguez |
| F | | Increased mobility and stem-cell proliferation rate in Dugesia tigrina induced by 880 nm light emitting diode | 630-880 nm (LEDs) - (0.00012 mW/cm2) | | 2011-(5) | Hsia-Pai Patrick Wu, Michael A. Persinger |
| A | | Signalling effect of NIR pulsed lasers on axonal growth | - | | 2010-(1) | Manoj Mathew, Ivan Amat-Roldana, Rosa Andrés, Susana I.C.O. Santos, David Artigas, Eduardo Soriano, Pablo Loza-Alvarez |
| A | | Biomodulation with low-level laser radiation induces changes in endothelial cell actin filaments and cytoskeletal organization | 685 nm - 8 J/cm2 | | 2009-(1) | R. Ricci, M. C. Pazos, R. Eller Borges, C. Pacheco-Soares |
| A | | The Effects of Light-Emitting Diode Irradiation at 610 nm and 710 nm on Murine T-Cell Subset Populations | 610-710 nm (LEDs) - 0.043 mW | | 2009-(1) | Jeong H. Lim, Jongmin Lee, Jida Choi, Jaewoo Hong, Hyunjhung Jhun, Jinsoo Han, and Soohyun Kim |
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|
| A | | Effects of Low-Level Light Therapy on Resting-State Connectivity Following Moderate Traumatic Brain Injury: Secondary Analyses of a Double-blinded Placebo-controlled Study | - | | 2024-(1) | Suk-tak Chan, Nathaniel Mercaldo, Maria G. Figueiro Longo, Jonathan Welt, Arman Avesta, Jarone Lee, Michael H. Lev, Eva-Maria Ratai, Michael R. Wenke, Blair A. Parry, Lynn Drake, Richard R. Anderson, Terry Rauch, Ramon Diaz-Arrastia, Kenneth K. Kwong, Michael Hamblin, Benjamin J. Vakoc, Rajiv Gupta |
| F | | Trajectories of Depressive Individual Symptoms over Time during Transcranial Photobiomodulation | 823 nm - (58.4 mW/cm2) 65.8 J/cm2 | | 2023-(9) | Minoru Urata, Paolo Cassano, Richard Norton, Katelyn M. Sylvester, Koichiro Watanabe, Dan V. Iosifescu, Hitoshi Sakurai |
| F | | Photons Induce Vesicular Exocytotic Release of Glutamate in a Power-Dependent Way | 810 nm | | 2023-(17) | Chiara Cervetto, Andrea Amaroli, Sarah Amato, Elena Gatta, Alberto Diaspro, Guido Maura, Antonio Signore, Stefano Benedicenti, Manuela Marcoli |
| F | | The effect of photobiomodulation on the brain during wakefulness and sleep | (review) | | 2022-(15) | Cecile Moro, Audrey Valverde, Marjorie Dole, Jaimie Hoh Kam, Catherine Hamilton, Ann Liebert, Brian Bicknell, Alim-Louis Benabid, Pierre Magistretti, John Mitrofanis |
| F | | Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer’s disease mouse model | 1070 nm - (25 mW/cm2) 4.5 J/cm2 | | 2021-(14) | Lechan Tao, Qi Liu, Fuli Zhang, Yuting Fu, Xi Zhu, Xiaofu Weng, Hongbin Han, Yong Huang, Yuanzhen Suo, Liang Chen, Xiaoling Gao, Xunbin Wei |
| F | | Photobiomodulation with 655-nm Laser Light to Induce the Differentiation of PC12 Cells | 655 nm - 1-5 J/cm2 | | 2020-(4) | Emel Bakay, Nermin Topaloglu |
| F | | The Effect of Photobiomodulation with Red and Near-Infrared Wavelengths on Keratinocyte Cells | 655 nm, 808 nm - 1-5 J/cm2 | | 2020-(4) | Merve Özmedir, Ziyşan Buse Yarali Çevik, Nermin Topaloglu |
| F | | Differential effects of photobiomodulation interval schedules on brain cytochrome c-oxidase and proto-oncogene expression | 670 nm - (50 mW/cm2) 9 J/cm2 | | 2020-(11) | Jorge L. Arias, Marta Mendez, Juan Ángel Martínez, Natalia Arias |
| A | | Neurite growth of trigeminal ganglion neurons in vitro with near-infrared light irradiation | 808 nm - 1-10 J/cm2 | | 2020-(1) | Heejoo Cho, Hee-Jae Jeon, Seonho Park, Chul-Seung Park, Euiheon Chung |
| F | | Photobiomodulation for Parkinson’s Disease in Animal Models: A Systematic Review | - | | 2020-(19) | Farzad Salehpour, Michael R Hamblin |
| F | | Near-infrared light increases functional connectivity with a non-thermal mechanism | 808 nm - (318 mW/cm2) | | 2020-(35) | Grzegorz M. Dmochowski, Ahmed (Duke) Shereen, Destiny Berisha, Jacek P. Dmochowski |
| A | | Transcranial Photobiomodulation with Near-Infrared Light for Generalized Anxiety Disorder: A Pilot Study | 830 nm - 36 J/cm2 | | 2019-(1) | Marco Maiello, Olivia M. Losiewicz, Eric Bui, Vincenza Spera, Michael R. Hamblin, Luana Marques, Paolo Cassano |
| F | | Pulsed Transcranial Red/Near-Infrared Light Therapy Using Light-Emitting Diodes Improves Cerebral Blood Flow and Cognitive Function in Veterans with Chronic Traumatic Brain Injury: A Case Series | 629-850 nm - (6.4 mW/cm2) | | 2018-(8) | S. Gregory Hipskind, Fred L. Grover Jr., T. Richard Fort, Dennis Helffenstein, Thomas J. Burke, Shane A. Quint, Garrett Bussiere, Michael Stone, Timothy Hurtado |
| F | | Photobiomodulation improves the frontal cognitive function of older adults | 633-870nm | | 2018-(9) | Agnes S. Chan, Tsz Lok Lee, Michael K. Yeung, Michael R. Hamblin |
| F | | Near infrared light to promote synaptic resilience to Alzheimer’s Disease neuropathology [thesis] | 670 nm - 4 J/cm2 | | 2018-(123) | Michele M. Comerota |
| F | | Transcranial near-infrared photobiomodulation attenuates memory impairment and hippocampal oxidative stress in sleep-deprived mice | 810 nm | | 2018-(22) | Farzad Salehpour, Fereshteh Farajdokht, Marjan Erfani, Saeed Sadigh-Eteghad, Siamak Sandoghchian Shotorbani, Michael R. Hamblin, Pouran Karimi, Seyed Hossein Rasta, Javad Mahmoudi |
| F | | Near infra-red light treatment of Alzheimer's disease | 1040-1090 nm (LEDs) - (15 mW/cm2) | | 2018-(8) | Mengmeng Han, Qiyan Wang, Xue Wang, Yuhui Zeng , Yong Huang , Qingqiang Meng , Jun Zhang, Xunbin We |
| F | | Photobiomodulation and the brain: a new paradigm | (review) | | 2016-(29) | Madison Hennessy, Michael R. Hamblin |
| A | | Acute Effects of Near Infrared Light Therapy on Brain State in Healthy Subjects as Quantified by qEEG Measures | 903 nm (LEDs) - (16.67 mW/cm2) | | 2016-(1) | Fred Grover Jr, Jon Weston, Michael Weston |
| A | | Transcranial, Red/Near-Infrared Light-Emitting Diode Therapy to Improve Cognition in Chronic Traumatic Brain Injury | 633-810 nm - (22.2 mW/cm2 each) | | 2016-(1) | Margaret A. Naeser, Paula I. Martin, Michael D. Ho, Maxine H. Krengel, Yelena Bogdanova, Jeffrey A. Knight, Megan K. Yee, Ross Zafonte, Judith Frazier, Michael R. Hamblin, Bang-Bon Koo |
| A | | Transcranial infrared laser stimulation improves rule-based, but not information-integration, category learning in humans | - | | 2016-(1) | Nathaniel J. Blancoa,, Celeste L. Saucedoa, F. Gonzalez-Lima |
| F | | Improved cognitive functions and behavioural response after exposure to low-level near-infrared laser in snails (Ariophanta laevipes) | 650 nm | | 2016-(8) | Contzen Pereira |
| F | | Review of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis | (review) | | 2016-(10) | Paolo Cassano, Samuel R. Petrie, Michael R. Hamblin, Theodore A. Henderson, Dan V. Iosifescu |
| F | | Far-infrared radiation protects viability in a cell model of Spinocerebellar Ataxia by preventing polyQ protein accumulation and improving mitochondrial function | - | | 2016-(11) | Jui-Chih Chang, Shey-Lin Wu, Fredrik Hoel, Yu-Shan Cheng, Ko-Hung Liu, Mingli Hsieh, August Hoel,3 Karl Johan Tronstad, Kuo-Chia Yan, Ching-Liang Hsieh, Wei-Yong Lin, Shou-Jen Kuo, Shih-Li Su, Chin-San Liu |
| F | | Near infrared radiation rescues mitochondrial dysfunction in cortical neurons after oxygen-glucose deprivation | - | | 2015-(12) | Zhanyang Yu, Ning Liu, Jianhua Zhao,Yadan Li, Thomas J. McCarthy, Clark E. Tedford, Eng H. Lo, Xiaoying Wang |
| F | | Augmentation of cognitive brain functions with transcranial lasers (mitocon.) | (review) | | 2014-(4) | F. Gonzalez-Lima, Douglas W. Barrett |
| F | | Significant Improvements in Cognitive Performance Post-Transcranial, Red/Near-Infrared Light-Emitting Diode Treatments in Chronic, Mild Traumatic Brain Injury: Open-Protocol Study | 630-870 nm (LEDs) - (22.2 mW/cm2 each) | | 2014-(10) | Margaret A. Naeser, Ross Zafonte, Maxine H. Krengel, Paula I. Martin, Judith Frazier, Michael R. Hamblin, Jeffrey A. Knight, William P. Meehan III, Errol H. Baker |
| F | | Transcranial low-level laser therapy enhances learning, memory, and neuroprogenitor cells after traumatic brain injury in mice | 810 nm - (25 mW/cm2) 18 J/cm2 | | 2014-(15) | Weijun Xuan, Fatma Vatansever, Liyi Huang, Michael R. Hamblinb |
| A | | Effect of 710 nm visible light irradiation on neurite outgrowth in primary rat cortical neurons following ischemic insult | 710 nm (LEDs) - (50mW/cm2) 4 J/cm2 | | 2012-(1) | Dong-Hee Choi, Kyoung-Hee Lee, Ji-Hye Kim, Moon Young Kim, Jeong Hoon Lim, Jongmin Lee |
| A | | Effect of 710-nm Visible Light Irradiation on Neuroprotection and Immune Function after Stroke | 710 nm | | 2012-(1) | Dong-Hee Choi, Kyoung-Hee Lee, Ji-Hye Kim, Moon Young Kim, Jeong Hoon Lim, Jongmin Lee |
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|
| A | | Photobiomodulation exerts anti-inflammatory effects on the vascular and cellular phases of experimental inflammatory models | 1-5 J/cm2 | | 2021-(1) | Mariana de Souza Costa, Tarcisio Vieira de Brito, Saul Barbosa de Oliveira, Isabela de Souza Brauna, José Carlos Rapozo Mazulo Neto, Ramon Handerson Gomes Teles, Yago Medeiros Dutra, Diva de Aguiar Magalhães, Stefany Guimarães Sousa, Janyere Alexandrino de Sousa, Carlos Eduardo Rodrigues Castelo Branco, Fuad Ahmad Hazime, André Luiz dos Reis Barbosa, Daniel Fernando Pereira Vasconcelos, Jand Venes Rolim Medeiros, Marcelo de Carvalho Filgueiras |
| A | | Photobiomodulation inhibits inflammation in the temporomandibular joint of rats | 808 nm - 50 J/cm2 | | 2021-(1) | Eliana de Souza Bastos Mazuqueli Pereira, Rosanna Tarkany Basting, Henrique Ballassini Abdalla, Aguinaldo Silva Garcez, Marcelo Henrique Napimoga, Juliana Trindade Clemente-Napimoga |
| A | | Low-level laser therapy attenuates lung inflammation and airway remodeling in a murine model of idiopathic pulmonary fibrosis: Relevance to cytokines secretion from lung structural cells | 780 nm - 3 J/cm2, 0.045 J/cm2 | | 2020-(1) | Auriléia Aparecida de Brito, Elaine Cristina da Silveira, Nicole Cristine Rigonato-Oliveira, Stephanie Souza Soares, Maysa Alves Rodrigues Brandao-Rangel, Clariana Rodrigues Soares, Tawany Gonçalves Santos, Cintia Estefano Alves, Karine Zanella Herculano, Rodolfo Paula Vieira, Adriana Lino-dos-Santos-Franco, Regiane Albertini, Flavio Aimbire, Ana Paula de Oliveira |
| A | | Influence of low-intensity radiation of the optical range spectrum (λ = 630-660 nm) on the immunoresistance parameters in animals with experimental peritonitis | 630-660 nm | | 2020-(1) | O. Klimova, A. Korobov, K. Bichenko, O. Lavinska, T. Kordon, L. Drozdova |
| F | | Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor | 660 nm - 3 J/cm2 | | 2018-(9) | Gabriel da Cunha Moraes, Luana Beatriz Vitoretti, Auriléia Aparecida de Brito, Cintia Estefano Alves, Nicole Cristine Rigonato de Oliveira, Alana dos Santos Dias, Yves Silva Teles Matos, Manoel Carneiro Oliveira-Junior, Luis Vicente Franco Oliveira, Renata Kelly da Palma, Larissa Carbonera Candeo, Adriana Lino-dos-Santos-Franco, Anna Carolina Ratto Tempestine Horliana, João Antonio Gimenes Júnior, Flavio Aimbire, Rodolfo Paula Vieira, Ana Paula Ligeiro-de-Oliveira |
| A | | Photobiomodulation Therapy Improves Acute Inflammatory Response in Mice: the Role of Cannabinoid Receptors/ATP-Sensitive K+ Channel/p38-MAPK Signalling Pathway | 660 nm - 50 J/cm2 | | 2017-(1) | Lais Mara Siqueira das Neves, Elaine Cristina Dalazen Gonçalves, Juliana Cavalli, Graziela Cleuza Vieira, Larissa R. Laurindo, Róli Rodrigues Simões, Igor dos Santos Coelho, Adair Roberto Soares dos Santos, A. Marcolino, Maira Miranda Cola, Rafael Dutra less |
| F | | Mechanisms and applications of the anti-inflammatory effects of photobiomodulation | (review) | | 2017-(25) | Michael R Hamblin |
| F | | Comparative study among three different phototherapy protocols to treat chemotherapy-induced oral mucositis in hamsters | 635 nm (LEDs), 660 nm | | 2016-(10) | Luana Campos, Érika P. Cruz, Filipi S. Pereira, Victor E. Arana-Chavez, Alyne Simões |
| F | | The role of near-infrared light-emitting diodes in aging adults related to inflammation | (review) | | 2015-(12) | Onyekachi Ibe, Erin Morency, Pablo Sosa, Lori Burkow-Heikkinen |
| F | | Effect of Prophylactic Low Level Laser Therapy on Oral Mucositis: A Systematic Review and Meta-Analysis | (review) | | 2014-(10) | Sapna Oberoi, Gabriele Zamperlini–Netto, Joseph Beyene, Nathaniel S. Treister, Lillian Sung |
| A | | 808 nm Wavelength Light Induces a Dose-Dependent Alteration in Microglial Polarization and Resultant Microglial Induced Neurite Growth | 808 nm - 0.2-30 J/cm2 | | 2013-(1) | Ramona E. von Leden, Sean J. Cooney, Teresa M. Ferrara, Yujia Zhao, Clifton L. Dalgard, Juanita J. Anders, Kimberly R. Byrnes |
| F | | Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients | (review) | | 2013-(9) | Cesar Migliorati, Ian Hewson |
| F | | Effects of 940 nm light-emitting diode (led) on sciatic nerve regeneration in rats | 940 nm (LEDs) - (9.5 mW/cm2) 4 J/cm2 | | 2011-(7) | Karla Guivernau Gaudens Serafim, Solange de Paula Ramos, Franciele Mendes de Lima, Marcelo Carandina, Osny Ferrari, Ivan Frederico Lupiano Dias, Dari de Oliveira Toginho Filho, Cláudia Patrícia Cardoso Martins Siqueira |
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|
| F | | Effects of photobiomodulation on the redox state of healthy and cancer cells | 780 nm - 5 J/cm2 | | 2021-(15) | Clara Maria Gonçalves de Faria, Heloisa Ciol, Vanderlei Salvador Bagnato, Sebastião Pratavieira |
| F | | Photobiomodulation induces murine macrophages polarization toward M2 phenotype | 945 nm (LEDs) - 3.6 J/cm2 | | 2021-(5) | Valdison P. Reis, Mauro V. Paloschi, Cristina M. A. Rego, Maria Naiara M. Tavares, Charles N. Boeno, Jéssica A. Lopes, Alex A. Ferreira e Ferreira, Andreimar M. Soares, Stella R. Zamuner, Juliana P. Zuliani |
| F | | Photobiomodulation, Energy and Cancer: A Quantum Notion | (review) | | 2021-(10) | Michael J. Gonzalez, José Olalde, Kenneth Cintron, Jorge R. Miranda-Massari, Michael H. Weber |
| F | | Effects of photobiomodulation on cellular viability and cancer stem cell phenotype in oral squamous cell carcinoma | 660 nm - 3-6 J/cm2 | | 2020-(10) | Ana Melissa Ccopa Ibarra, Mônica Pereira Garcia, Marlene Ferreira, Daniela de Fátima Teixeira da Silva, Christiane Pavani, Raquel Agnelli Mesquita-Ferrari, Kristianne Porta Santos Fernandes, Fabio Daumas Nunes, Maria Fernanda Setúbal Destro Rodrigues |
| A | | Low-level laser irradiation potentiates anticancer activity of p-coumaric acid against human malignant melanoma cells | 660 nm - 1-6 J/cm2 | | 2020-(1) | Zahra Kianmehr, Khatereh Khorsandi, Maryam Mohammadi, Rezab Hosseinzadeh |
| A | | Cellular transformations in near-infrared light-induced apoptosis in cancer cells revealed by label-free CARS imaging | 808 nm - 0.3-30 J/cm2 | | 2019-(1) | Svitlana M. Levchenko, Andrey N. Kuzmin, Artem Pliss, Tymish Y. Ohulchanskyy, Paras N. Prasad, Junle Qu |
| A | | Low-Level Laser Therapy May Have Cancer Fighting Role | - | | 2016-(0) | Lars Hode |
| F | | Quantitative Proteomics Reveals Middle Infrared Radiation-Interfered Networks in Breast Cancer Cells | 3000-5000 nm | | 2015-(13) | Hsin-Yi Chang, Ming-Hua Li, Tsui-Chin Huang, Chia-Lang Hsu, Shang-Ru Tsai, Si-Chen Lee, Hsuan-Cheng Huang, Hsueh-Fen Juan |
| A | | Selective cytotoxic effects of low-power laser irradiation on human oral cancer cells | 810 nm - 10-60 J/cm2 | | 2015-(1) | Wei-Zhe Liang, Pei-Feng Liu, Earl Fu, Hao-Sheng Chung, Chung-Ren Jan, Chih-Hsuan Wu, Chih-Wen Shu, Yao-Dung Hsieh |
| F | | Cancer Phototherapy via Selective Photoinactivation of Respiratory Chain Oxidase to Trigger a Fatal Superoxide Anion Burst (mitocon.) | 635 nm - (112 mW/cm2), etc. | | 2014-(14) | Shengnan Wu, Feifan Zhou, Yanchun Wei, Wei R. Chen, Qun Chen, Da Xing |
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|
| A | | Assessment of Effects of Low-Level Light Therapy on Scalp Condition and Hair Growth | 630-970 nm | | 2023-(1) | Jin Hee Kim, Hyung Seok Son, Da-Ae Yu, Yong Beom Choe, Yang Won Lee |
| F | | Photobiomodulation for Correction of Systemic Disorders of Experimental Pain Syndromes | 810 nm - 6 J/cm2 (55 mW/cm2) | | 2023-(10) | Alla G. Polyakova, Anna G. Soloveva, Petr V. Peretyagin, Anna N. Belova, Kseniya L. Belyaeva |
| F | | LIGHTSITE II Randomized Multicenter Trial: Evaluation of Multiwavelength Photobiomodulation in Non-exudative Age-Related Macular Degeneration | 590 nm + 660 nm + 850 nm (4 + 65 + 0.6 mW/cm2) | | 2023-(16) | Ben Burton, Maurizio Battaglia Parodi, Ignasi Jürgens, Xavier Zanlonghi, Dan Hornan, Johann Roider, Katrin Lorenz, Marion R. Munk, Cindy L. Croissant, Stephanie E. Tedford, Michael Walker, Rene Ruckert, Clark E. Tedford |
| F | | The effects of low power laser light at 661 nm on wound healing in a scratch assay fibroblast model | 661 nm - 3-4.5 J/cm2 | | 2023-(9) | Efstathios Giannakopoulos, Annita Katopodi, Michail Rallis, Konstantinos Politopoulos, Eleni Alexandratou |
| F | | Photobiomodulation assay of muscle cells C2C12 after irradiation with LED device | 660 nm `+ 850 nm - (5.6 mW/cm2) 3.4 J/cm2 | | 2022-(11) | Elessandro Váguino de Lima, Cristina Pacheco-Soares, Newton Soares da Silva |
| F | | Comparative study on Photobiomodulation between 630 nm and 810 nm LED in diabetic wound healing both in vitro and in vivo | 630 nm, 810 nm - (1-10 mW/cm2) | | 2022-(10) | Hongyou Zhao, Tengda Ji, Tianzhen Sun, Haolin Liu, Yidi Liu, Defu Chen, Ying Wang, Yizhou Tan, Jing Zeng, Haixia Qiu, Ying Gu |
| F | | 670nm photobiomodulation modulates bioenergetics and oxidative stress, in rat Müller cells challenged with high glucose | 670 nm - 4.5 J/cm2 | | 2021-(14) | Hannah J. Nonarath, Alexandria E. Hall, Gopika SenthilKumar, Betsy Abroe, Janis T. Eells, Elizabeth S. Liedhegne |
| F | | Novel Application of Light-Emitting Diode Therapy in the Treatment of Eyebrow Loss in Frontal Fibrosing Alopecia | 665 nm - 37 J/cm2 (68 mW/cm2) | | 2021-(10) | Agnieszka Gerkowicz, Joanna Bartosińska, Dorota Raczkiewicz, Mirosław Kwaśny, Dorota Krasowska |
| F | | Efficacy of low level laser therapy in nerve injury repair—a new era in therapeutic agents and regenerative treatments | (review) | | 2021-(15) | Xellen Cunha Muniz, Ana Carolina Correa de Assis, Bruna Stefane Alves de Oliveira, Luiz Fernando Romanholo Ferreira, Muhammad Bilal, Hafiz M. N. Iqbal, Renato Nery Soriano |
| A | | Photobiomodulation Therapy on Myocardial Infarction in Rats: Transcriptional and Posttranscriptional Implications to Cardiac Remodeling | 660 nm - 1.15 J/cm2 | | 2021-(1) | Regiane dos Santos Feliciano, Allan Luís Barboza Atum, Érico Gustavo da Silva Ruiz, Andrey Jorge Serra, Ednei Luiz Antônio Martha Trindade Manchini, Jairo Montemor Augusto Silva, Paulo José Ferreira Tucci, Lubov Nathanson, Mariana Morris, Maria Cristina Chavantes, José Antônio Silva Júnior |
| A | | Photobiomodulation effect of red LED (630 nm) on the free radical levels produced by pulp cells under stress conditions | 630 nm - 4-30 J/cm2 (40-80 mW/cm2) | | 2021-(1) | Jéssica Fernanda Sena Bonvicini, Fernanda Gonçalves Basso, Carlos Alberto de Souza Costa, Carlos José Soares, Ana Paula Turrioni |
| F | | Effects of Low-Level Laser Therapy on Reactive Oxygen Species, Platelet Aggregation Activity, and the Expression of Growth Factors in the Process of Regeneration of Chronic Wounds | 660 nm - 1 J/cm2 | | 2021-(9) | Nataliia Babenko, Sergey Pavlov |
| F | | Photobiomodulation invigorating collagen deposition, proliferating cell nuclear antigen and Ki67 expression during dermal wound repair in mice | 632 nm - 2-4 J/cm2 | | 2020-(10) | Vijendra Prabhu, Bola Sadashiva Satish Rao, Anuradha Calicut Kini Rao, Keerthana Prasad, Krishna Kishore Mahato |
| F | | 830 nm photobiomodulation therapy promotes engraftment of human umbilical cord blood derived hematopoietic stem cells | 830 nm - 2 J/cm2 | | 2020-(8) | Jingke Yang, Li Wang, Mei X. Wu |
| A | | Ergogenic Effects of Photobiomodulation on Performance in the 30-Second Wingate Test A Randomized, Double-Blind, Placebo-Controlled, Crossover Study | 630 nm - 4.6 J/cm2 | | 2020-(1) | Julio C. Molina Correa, Susana Padoin, Pedro Varoni, Michelli Demarchi, Lucinar Flores, Fernando Nampo, Solange de Paula Ramos |
| F | | Light-emitting diode photobiomodulation therapy for non-specific low back pain in working nurses A single-center, double-blind, prospective, randomized controlled trial | 630 nm + 850 nm - (8 mW/cm2 + 14 mW/cm2) | | 2020-(6) | Yen-Po Lin, Ying-Hao Su, Shih-Fang Chin, Yu-Ching Chou, Wei-Tso Chia |
| A | | Sunlight and health: shifting the focus from vitamin D3 to photobiomodulation by red and near-infrared light | - | | 2020-(1) | Vladimir Heiskanen, Morgan Pfiffner, Timo Partonen |
| F | | Photobiomodulation and the expression of genes related to the JAK/STAT signalling pathway in wounded and diabetic wounded cells | 660 nm - 5 J/cm2 | | 2020-(1) | Sandy Winfield Jere, Nicolette Nadene Houreld, Heidi Abrahamse |
| A | | Light-emitting diode irradiation using 660 nm promotes human fibroblast HSP90 expression and changes cellular activity and morphology | 660 nm | | 2019-(1) | Sun-Hyang Choi, So-Young Chang, Raktim Biswas, Phil-Sang Chung, Sangjoon Mo, Min Young Lee, Jin Chul Ahn |
| A | | Photobiomodulation of the microbiome: implications for metabolic and inflammatory diseases | 660 nm, 808 nm | | 2018-(1) | Brian Bicknell, Ann Liebert, Daniel Johnstone, Hosen Kiat |
| F | | Mitochondrial dynamics (fission and fusion) and collagen production in a rat model of diabetic wound healing treated by photobiomodulation: comparison of 904 nm laser and 850 nm light-emitting diode (LED) | 850 nm, 904 nm - 14-18 J/cm2 | | 2018-(7) | José Carlos Tatmatsu-Rocha, Carla Roberta Tim, Lucimar Avo, Rubens Bernardes-Filho, Patricia Brassolatti, Hueliton Wilian Kido, Michael R. Hamblin, Nivaldo Antonio Parizotto |
| F | | The influence of low level laser irradiation on vascular reactivity | 10-110 mW | | 2018-(4) | Magdelena Mackiewicz-Milewska, Elżbieta Grześk, Andrzej C. Kroszczyński, Małgorzata Cisowska-Adamiak, Hanna Mackiewicz-Nartowicz, Lilianna Baran, Iwona Szymkuć-Bukowska, Michał Wiciński, Wojciech Hagner, Grzegorz Grześk |
| A | | Effect of low-level laser therapy on the healing process of donor site in patients with grade 3 burn ulcer after skin graft surgery (a randomized clinical trial) | 655 nm - 2 J/cm2 | | 2018-(1) | Reza Vaghardoost, Mahnoush Momeni, Nooshafarin Kazemikhoo, Soheila Mokmeli, Mostafa Dahmardehei, Fereshteh Ansari, Mohammad Ali Nilforoushzadeh, Parisa Sabr joo, Sara Mey Abadi, Soheila Naderi Gharagheshlagh, Saeed Sassani |
| F | | Laser induced differentiation of human adipose stem cells to functional neuronal cells [thesis] | 630 nm, 825 nm - 5-25 J/cm2 | | 2017-(182) | Sajan George |
| A | | Far infrared promotes wound healing through activation of Notch1 signaling | - | | 2017-(30) | Yung-Ho Hsu, Yuan-Feng Lin, Cheng-Hsien Chen, Yu-Jhe Chiu, Hui-Wen Chiu |
| F | | Biological effects and medical applications of infrared radiation | (review) | | 2017-(1) | Shang-Ru, Tsai, Michael R. Hamblin |
| F | | A Role for Photobiomodulation in the Prevention of Myocardial Ischemic Reperfusion Injury: A Systematic Review and Potential Molecular Mechanisms | (review) | | 2017-(13) | Ann Liebert , Andrew Krause, Neil Goonetilleke, Brian Bicknell, Hosen Kiat |
| F | | Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age-related macular degeneration | 590-790 nm 0.1-7.68 J/cm2 | | 2016-(8) | Graham F. Merry, Marion R. Munk, Robert S. Dotson, Michael G. Walker, Robert G. Deven |
| F | | Specific LED-based red light photo-stimulation procedures improve overall sperm function and reproductive performance of boar ejaculates | 620-630 nm | | 2016-(13) | Marc Yeste, Francesc Codony, Efrén Estrada, Miquel Lleonart, Sam Balasch, Alejandro Peña, Sergi Bonet, Joan E. Rodríguez-Gil |
| F | | Effect of low-level laser therapy on angiogenesis and matrix metalloproteinase-2 immunoexpression in wound repair | 660 nm - 4 J/cm2 | | 2016-(9) | Melyssa Lima de Medeiros, Irami Araújo-Filho, Efigênia Maria Nogueira da Silva,Wennye Scarlat de Sousa Queiroz, Ciro Dantas Soares, Maria Goretti Freire de Carvalho, Maria Aparecida Medeiros Maciel |
| F | | Phototherapy with combination of super-pulsed laser and light-emitting diodes is beneficial in improvement of muscular performance (strength and muscular endurance), dyspnea, and fatigue sensation in patients with chronic obstructive pulmonary disease | 640 nm + 875 nm + 905 nm | | 2015-(7) | Eduardo Foschini Miranda, Luís Vicente Franco de Oliveira, Fernanda Colella Antonialli, Adriane Aver Vanin, Paulo de Tarso Camillo de Carvalho, Ernesto Cesar Pinto Leal-Junior |
| F | | Effect of Low Power Laser Irradiation on the Ability of Cell Growth and Myogenic Differentiation of Myoblasts Cultured In Vitro (regeneration) | 632.8 nm - (6 mW/cm2) 0.3-6.3 J/cm2 | | 2014-(8) | Cui-Ping Zhang, Shao-Dan Li, Yan Chen, Yan-Ming Jiang, Peng Chen, Chang-Zhen Wang, Xiao-Bing Fu, Hong-Xiang Kang, Ben-Jian Shen, Jie Liang |
| F | | Stimulative Effects of Low Intensity He-Ne Laser Irradiation on the Proliferative Potential and Cell-Cycle Progression of Myoblasts in Culture (regeneration) | 632.8 nm - (6 mW/cm2) | | 2014-(9) | Cui-Ping Zhang, Shao-Dan Li, Yan Chen, Yan-Ming Jiang, Peng Chen, Chang-Zhen Wang, Xiao-Bing Fu, Hong-Xiang Kang, Ben-Jian Shen, Jie Liang |
| F | | A Controlled Trial to Determine the Efficacy of Red and Near-Infrared Light Treatment in Patient Satisfaction, Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase (rejuvenation) | 611–650, 570–850 nm - 9 J/cm2 | | 2014-(8) | Alexander Wunsch, Karsten Matuschka |
| F | | Photobiomodulation on Bax and Bcl-2 Proteins and SIRT1/PGC-1α Axis mRNA Expression Levels of Aging Rat Skeletal Muscle | 810 nm - (125 mW/cm2) 3.75 J/cm2 | | 2014-(9) | Fang-Hui Li, Yan-Ying Liu, Fei Qin, Qing Luo, Hai-Ping Yang, Quan-Guang Zhang, Timon Cheng-Yi Liu |
.
.
