Comparative study on Photobiomodulation between 630 nm and 810 nm LED in diabetic wound healing both in vitro and in vivo

" Our results showed that both 630nm and 810nm LED irradiation significantly promoted the proliferation of mouse fibroblast cells (L929) at different light irradiances (1, 5, and 10mW/cm2). The cell proliferation rate increased with the extension of irradiation time (100, 200, and 500s), but it decreased when the irradiation time was over 500s. Both 630nm and 810nm LED irradiation (5mW/cm2) significantly improved the migration capability of L929 cells. No difference between 630nm and 810nm LED-mediated PBM in promoting cell proliferation and migration was detected. In vivo results presented that both 630nm and 810nm LED irradiation promoted the wound healing and the expression of the vascular endothelial growth factor (VEGF) and transforming growth factor (TGF) in the wounded skin of type 2 diabetic mice. Overall, these results suggested that LED-mediated PBM promotes wound healing of diabetic mice through promoting fibroblast cell proliferation, migration, and the expression of growth factors in the wounded skin. LEDs (630nm and 810nm) have a similar outcome in promoting wound healing of type 2 diabetic mice." {Credits 1}

{Credits 1} 🎪 Zhao, H., Ji, T., Sun, T., Liu, H., Liu, Y., Chen, D., ... & Gu, Y. (2022). Comparative study on Photobiomodulation between 630 nm and 810 nm LED in diabetic wound healing both in vitro and in vivo. Journal of Innovative Optical Health Sciences, 2250010. © 2022 The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License.