Cell Responsiveness to Physical Energies Paving the Way to Decipher a Morphogenetic Code

" Compelling evidence is presented, showing that biological patterns are strongly embedded in the vibrational nature of the physical energies that permeate the entire universe. We describe biological dynamics as informational processes at which physics and chemistry converge, with nanomechanical motions, and electromagnetic waves, including light, forming an ensemble of vibrations, acting as a sort of control software for molecular patterning." {Credits 1}

" A single peptide molecule can be viewed as an array of repetitive helix–loop–helix domains. These modules are intrinsically oscillatory, with the helix acting as a spring (oscillator) and the loops as inter-oscillator linkers. However, these springs are highly polarized, with arrays of positively charged amino groups (such as those in lysine and arginine) and negatively charged carboxyl groups (such as those in aspartate and glutamate)." {Credits 1}

" The RRM is a method that treats the sequence of proteins and other signaling molecules, including DNA, as a precise signal, based upon evidence that defined vibrational frequencies (periodicities) in this signal characterize the biological function of molecules [32,33]. RRM is based upon the finding that protein function may be controlled by periodic distribution in the energy of their delocalized electrons, ... protein conductivity could be associated with defined spectral signatures, resulting from electromagnetic radiation/absorption patterns generated by the flow of electric charges through the protein backbone [ 34 , 35 ]." {Credits 1}

" In fact, STM, coupled with an artificial cell replica developed to deliver electromagnetic fields of specific frequencies to tubulin molecules assembling onto platinum nanoelectrodes, has shown that tubulins, tubulin dimers, and microtubules exhibited electric conductivity profiles resonating only with specific electromagnetic frequencies applied through the cell replica system [5]. ... these findings further support the notion that mechanical and electromagnetic resonance modes can coexist and affect each other within the same molecular network (as it has been shown for tubulins and microtubuli)." {Credits 1}

" Compelling evidence for previously unexpected features of microtubuli came from the discovery that they even entail multi-level memory-switching properties. By the aid of sophisticated STM analyses, the formation of these memory states has been found to involve vibrational (mechanical and electromagnetic) modes that control protein arrangement symmetry related to the conducting state written within the nanowire structure of the microtubule." {Credits 1}

" An overall picture emerges where the microtubular network, and more generally, the cytoskeleton, can be regarded as a complex “bioelectronic circuit”, capable of generating a continuous flow of information fashioned as a multitude of self-organizing vibrations, emerging and diffusing as short- and long-range mechanical/electromagnetic (including light) oscillatory patterns. This bioelectronic circuit is also the context where biomolecular recognition and further information is generated. In fact, the extremely high speed and coordinated tuning of molecular interplay at the basis of complex cellular decisions, including the orchestration of stem cell fate, cannot be solely explained by the diffusion and collision of molecules within the aqueous intracellular environment." {Credits 1}

" Within the context discussed herein, microtubuli may be considered as an elastic matrix of nanowires capable of mechanical and electromagnetic oscillatory patterns with radiation characteristics, while, taking into account the previously discussed RRM [32,33,34,35], signaling molecules may be equated to oscillators, behaving as resonators for frequencies in the range of 1013–1015 Hz, consonant with the length of amino acid chains." {Credits 1}

" Like a symphony, in the cellular orchestra we may envision multiple coherent domains, each with a population of oscillators synchronized on specific frequencies, waveforms, and/or pause intervals. An additional level of self-organization may be achieved through the swarming of multiple coherent domains, each retaining their internal state of synchronization while migrating across the cell." {Credits 1}

" Using the lattice details of human DNA, the radiation of DNA has been modeled as a helical antenna, with the DNA structure resonating with electromagnetic waves at 34 GHz, with a positive gain of 1.7 dBi [91]." {Credits 1}

{Credits 1} 🎪 Tassinari, R.; Cavallini, C.; Olivi, E.; Facchin, F.; Taglioli, V.; Zannini, C.; Marcuzzi, M.; Ventura, C. Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code. Int. J. Mol. Sci. 2022, 23, 3157. https://doi.org/10.3390/ijms23063157. © 2022 the Author(s). This open access article is distributed under Creative Commons Attribution License.

Last modified on 18-Mar-22

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