Explanation of Osteoblastic Differentiation of Stem Cells by Photo Biomodulation Using the Resonant Recognition Model

" Here, we hypothesised that stimulation of osteoblast differentiation by specific blue and green light wavelengths is related to activation of proteins involved in osteoblast differentiation like PTH and SDF-1α. For this purpose, we have utilised the RRM model, which proposes that protein activation and function are based on specific wavelengths (frequencies) of electromagnetic radiation within ultra-violet, visible, infra-red and far infra-red light. Thus, by using the RRM, we have analysed the parathyroid hormone, its receptor and stromal self-derived factor with the aim to predict the characteristic wavelengths (frequencies) related to parathyroid hormone activities, particularly differentiation of stem cells into osteoblasts." {Credits 1}

" We have found that the most effective wavelength for stem cell differentiation would be 502 nm, which is between 420 nm and 540 nm, already experimentally proven to be effective in stimulating osteoblast differentiation. Thus, we propose that wavelength radiation of 502 nm will be even more efficient for differentiation of stem cells into osteoblasts." {Credits 1}

{Credits 1} 🎪 Cosic, I., Paspaliaris, V., & Cosic, D. (2019). Explanation of Osteoblastic Differentiation of Stem Cells by Photo Biomodulation Using the Resonant Recognition Model. Applied Sciences, 9(10), 1979. © 2019 The Author(s). This article is published under the terms of the Creative Commons Attribution License 4.0.