Timing of phase-amplitude coupling is essential for neuronal and functional maturation of audiovisual integration in adolescents

" The ability to integrate audiovisual information matures late in adolescents, but its neuronal mechanism is still unknown. Recent studies showed that phase‐amplitude coupling (PAC) of neuronal oscillations, which is defined as the modulation of high‐frequency amplitude by low‐frequency phase, is associated with audiovisual integration in adults. ... Whereas delta‐beta coupling was consistently observed in both adults and adolescents, we found that the timing of delta‐beta PAC was delayed by 20–40 milliseconds in adolescents compared with adults. ... These results suggest that the timing of PAC is essential for binding audiovisual information and underlies the developmental process in adolescents." {Credits 1}

{Credits 1} 🎪 Ohki, T., Matsuda, T., Gunji, A., Takei, Y., Sakuma, R., Kaneko, Y., ... & Hiraki, K. (2020). Timing of phase‐amplitude coupling is essential for neuronal and functional maturation of audiovisual integration in adolescents. Brain and Behavior, e01635. © 2020 The Authors. This article is licensed under a Creative Commons Attribution License.