Synaptic transmission modulates while non-synaptic processes govern the transition from pre-ictal to seizure activity in vitro

" It is well established that non-synaptic mechanisms can generate electrographic seizures after blockade of synaptic function. We investigated the interaction of intact synaptic activity with non-synaptic mechanisms in the isolated CA1 region of rat hippocampal slices using the 'elevated-K+' model of epilepsy. ... Our results are consistent with the hypothesis that non-synaptic mechanisms underpin the generation of ictal bursts in CA1 and that GABAA synaptic mechanisms can shape event development by delaying event initiation and counteracting depolarization block." {Credits 1}

{Credits 1} 🎪 Bikson, M., Ruiz-Nuño, A., Miranda, D., Kronberg, G., Jiruska, P., Fox, J. E., & Jefferys, J. G. (2018). Synaptic transmission modulates while non-synaptic processes govern the transition from pre-ictal to seizure activity in vitro. bioRxiv, 280321. © The Author(s). This is an open access article distributed under the terms of the CC-BY-NC-ND 4.0 International license.