Clustering of atomic displacement parameters in bovine trypsin reveals a distributed lattice of atoms with shared chemical properties

" In this paper, we observe the protein atoms directly using X-ray crystallography in bovine trypsin at 100 K while irradiating the crystals with 0.5 THz radiation alternating on and off states. We observed that the anisotropy of atomic displacements increased upon terahertz irradiation. Atomic displacement similarities developed between chemically related atoms and between atoms of the catalytic machinery. This pattern likely arises from delocalized polar vibrational modes rather than delocalized elastic deformations or rigid-body displacements." {Credits 1}

" Fröhlich proposed an alternative to the canonical probability distribution (commonly referred to as Fröhlich condensation) [9], which may be more appropriate for non-isolated biological dissipative systems. In this out-of-equilibrium model, the probability distribution is skewed towards the lowest frequency mode in a coupled oscillator system. ... Collective modes in biological systems are postulated to play a role in long-range protein-protein interactions, the adjustment of biochemical reaction rates and information processing in semicrystalline, supramolecular systems." {Credits 1}

{Credits 1} 🎪 Gagnér, V.A., Lundholm, I., Garcia-Bonete, M. et al. Clustering of atomic displacement parameters in bovine trypsin reveals a distributed lattice of atoms with shared chemical properties. Sci Rep 9, 19281 (2019). © 2019 The Author(s). This is an open access article distributed under the terms of the CC-BY 4.0 license.