Disturbance of bioelectric transmission in carcinogenesis

" ... The above data indicates that the “decision” of a certain part of the body to develop a tumor depends on the bioelectric state of remote regions. In this context, the prognosis and treatment of malignant neoplasms can most likely be achieved not by local, gene-targeting technology, but by methods for the detection of tumor signatures in the morphogenetic field of the organism." {Credits 1}

It reviews various experimental discoveries that bring curious data and profound significances, for example:

" ... It is important to mention that the same effect was obtained using any method of depolarization of Vmem (by modulating chlorine, sodium, potassium, or hydrogen channels). This in turn indicates the primary role of a purely physiological perturbation – disturbance in Vmem in the appearance of a metastatic phenotype, and not in case of any specific gene product or ionic disturbances." {Credits 1}

{Credits 1} 🎪 Draguta, Ilarion, Mustea, Anatolie, Popescu, Constantin, Iurcu, Cornel, & Palade, Valeriu. (2019). Disturbance of bioelectric transmission in carcinogenesis. Moldovan Medical Journal, 62 (2), 33–37. http://doi.org/10.5281/zenodo.3233923. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0.

Last modified on 07-Dec-19

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