Exposed rats: Increased Malondialdehyde levels. Decreased liver tissue glutathione levels. Increased Serum Ca2+, alanine transaminase, and aspartate aminotransferase levels. Increased total oxidant status levels and decreased total antioxidant status levels in the liver tissue. Extensive vacuolation and degeneration of the hepatocytes in the portal area, as well as those surrounding the sinusoids. Affected hepatocytes had polygonally shaped nuclei and vacuolic cytoplasm imparting eosinophilic staining. Decreased cellular membrane integrity and invaginations, as well as picnotic nuclei. |
Last modified on 17-Oct-21 |