Exposure to 1.8 GHz radiofrequency field modulates ROS in human HEK293 cells as a function of signal amplitude


" Here, we show that exposure to a 1.8 GHz carrier frequency in the amplitude range of household telecommunications induces the formation of ROS (Reactive Oxygen Species) in human HEK293 cultured cells. The ROS concentrations detected by fluorescent imaging techniques increased significantly after 15 minutes of RF field exposure, and were localized to both nuclear and cytosolic cellular compartments. qPCR analysis showed altered gene expression of both anti-oxidative (SOD, GPX, GPX, and CAT) and oxidative (Nox-2) enzymes. In addition, multiple genes previously identified as responsive to static magnetic fields were found to also be regulated by RF, suggesting common features in response mechanisms. By contrast, many RF effects showed evidence of hormesis, whereby biological responsivity does not occur linearly as a function of signal amplitude. Instead, biphasic dose response curves occur with ‘blind’ spots at certain signal amplitudes where no measureable response occurs. We conclude that modulation of intracellular ROS can be a direct consequence of RF exposure dependent on signal frequency and amplitude." {Credits 1}

{Credits 1} 🎪 Marootpong Pooam, Nathalie Jourdan, Blanche Aguida, Cyril Dahon, Soria Baouz, Colin Terry, Haider Raad & Margaret Ahmad (2022) Exposure to 1.8 GHz radiofrequency field modulates ROS in human HEK293 cells as a function of signal amplitude, Communicative & Integrative Biology, 15:1, 54-66, DOI: 10.1080/19420889.2022.2027698. © 2022 The Author(s). This is an open access article under the Creative Commons Attribution 4.0 International License.


Last modified on 08-Mar-22

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