The endocannabinoid system is involved in the anxiety-like behavior induced by dual-frequency 2.65/0.8 GHz electromagnetic radiation in mice

" Remarkably, administering the cannabinoid receptor agonist Win55-212-2 significantly alleviated the anxiety-like behavior, and the cannabinoid receptor antagonist AM251 effectively counteracted the anti-anxiety effects of Win55-212-2. In summary, our research confirmed that dual-frequency EMR is more likely to induce anxiety-like behavior in mice than single-frequency EMR, with implications for the hypothalamic–pituitary–adrenal axis and the endocannabinoid system. Furthermore, our findings suggest that Win55-212-2 may represent a novel avenue for researching and developing anti-EMR drugs." {Credits 1}

{Credits 1} 🎪 Xue T, Ma R-H, Xu C, Sun B, Yan D-F, Liu X-M, Gao D, Li Z-H, Gao Y and Wang C-Z (2024) The endocannabinoid system is involved in the anxiety-like behavior induced by dual-frequency 2.65/0.8 GHz electromagnetic radiation in mice. Front. Mol. Neurosci. 17:1366855. doi: 10.3389/fnmol.2024.1366855. © 2024 The author(s). This article is distributed under the terms of the Creative Commons Attribution License.