The frequency-dependent effect of electrical fields on the mobility of intracellular vesicles in astrocytes


" We applied electrical stimulation with voltages comparable to in vivo sleep recordings over a range of frequencies to cultured glial astrocytes while monitored the trafficking of GFP-tagged intracellular vesicles using total internal reflection fluorescence microscopy (TIRFM). We found that during low frequency (2 Hz) electrical stimulation the mobility of intracellular vesicle increased more than 20%, but remained unchanged under intermediate (20 Hz) or higher (200 Hz) frequency stimulation. We demonstrated a frequency-dependent effect of electrical stimulation on the mobility of astrocytic intracellular vesicles." {Credits 1}

{Credits 1} 🎪 Y. Wang, T.P. Burghardt, G.A. Worrell et al., The frequency-dependent effect of electrical fields on the mobility of intracellular vesicles in astrocytes, Biochemical and Biophysical Research Communications, https://doi.org/10.1016/j.bbrc.2020.11.064. © 2020 The Authors. This is an open access article distributed under the terms of the CC BY-NC-ND License.


Last modified on 05-Oct-21

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