Theoretical investigation on the effect of terahertz wave on Ca2+ transport in the calcium channel

" In this work, we established a mathematical physical model of the Ca2+ channel by the Brownian dynamic method. The time domain and frequency domain characteristics of calcium ion movement in the channel have been analyzed. The results show that the Ca2+ transmembrane transport is a rapid signal change process on a short timescale, and its spontaneous radiation spectrum is mainly concentrated in the THz range. Meanwhile, the changes in temperature and the number of ions in the channel were proved to have significant effects on the spectral characteristics, as the frequency increases, the radiation spectrum of calcium ions shifted toward higher frequencies. In addition, under the external THz field irradiation, the oscillation spectrum of the irritated Ca2+ is significantly enhanced, which is expected to be applied in future nondestructive testing. It was also found from the simulation results that the transport process of Ca2+ across the ion channel is related to the frequency and amplitude of the THz wave. Under a certain amplitude, the ion permeability gradually increases as the frequency of the THz field increases; under a certain frequency, the ion permeability also increases as the amplitude increases. The finding in this paper provides a theoretical basis for the future treatment of THz waves in the neurological field." {Credits 1}

{Credits 1} 🎪 Guo, L., Bo, W., Wang, K., Wang, S., & Gong, Y. (2021). Theoretical Investigation on the Effect of Terahertz Wave on Ca2+ Transport in the Calcium Channel. iScience, 103561. © 2021 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 License.