A high throughput screening system of coils for ELF magnetic fields experiments proof of concept on the proliferation of cancer cell lines

" For the U251 cells, a total of 180 different exposures were tested in three different experiments. Depending on exposure modulation and AC field intensity (but, remarkably, not on DC intensity), we found the three possible outcomes: increase (14.3% above control, p < 0.01), decrease (16.6% below control, p < 0.001), and also no-effect on proliferation with respect to control. Only the time modulation that inhibited proliferation of U251 was also tested on MDA-MB-231 cells which, in contrast, showed no alteration of their proliferation on any of the 60 AC/DC field combinations tested." {Credits 1}

" We demonstrated, for the first time, the use of a novel system of coils for magnetobiology research, which allowed us to find that differences of only a few μT resulted in statistically different results. Not only does our study demonstrate the relevance of the time modulation and the importance of finely sweeping through the AC and DC amplitudes, but also, and most importantly, provides a proof of concept of a system that sensibly reduces the time and costs of screening." {Credits 1}

{Credits 1} 🎪 Makinistian, L., Marková, E. & Belyaev, I. A high throughput screening system of coils for ELF magnetic fields experiments: proof of concept on the proliferation of cancer cell lines. BMC Cancer 19, 188 (2019). https://doi.org/10.1186/s12885-019-5376-z. © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.